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Galectin-12, also designated galectin-related inhibitor of proliferation 1 in mouse, is a 314 amino acid protein encoded by the human gene LGALS12. Galectin-12 is a member of the galectin family consisting of b-galactoside-binding proteins with conserved carbohydrate recognition domains. Galectin-12 binds lactose and may participate in the apoptosis of adipocytes. This protein is preferentially expressed in peripheral blood leukocytes and adipocytes. Galectin-12 is induced by cell cycle block at the G1 phase and causes G1 arrest when overexpressed. The galectin-12 gene is expressed in mouse preadipo-cytes and is upregulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation. Galectin-12 is an adipocyte-expressed protein which is downregulated by various insulin resistance-inducing hormones. As a result, galectin-12 may play a role in the pathogenesis of insulin resistance.
AW987437; GAL12; gal-12; galectin 12; galectin-12; Galectin-related inhibitor of proliferation; galectin-related inhibitor of proliferation 1; GRIP1; lectin, galactose binding, soluble 12; lectin, galactoside binding soluble 12; lectin, galactoside-binding, soluble, 12; LGALS12; testicular secretory protein Li 26
100 µg
100 µL
50 µg
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